Biomimetic and Methodology Based Total Synthesis of Bioactive Natural Products

Grant number: DP0770408

Abstract

The proposal will study the synthesis of novel natural products that possess biological activities. Most significantly, this project will deliver compounds with anticancer activity. In addition, chemistry may be developed which could be utilised to synthesise a number of bioactive molecules. The rewards of the synthesis of compounds and application for the treatment of cancer and other diseases are enormous for the community and in the education and training of scientists.

Related publications (2)

Stereoselective total synthesis of (-)-spirofungin a by utilising hydrogen-bond controlled spiroketalisation

JE Lynch, SD Zanatta, JM White, MA Rizzacasa

2011-01-03

The stereoselective total synthesis of the spiroketal containing Streptomyces metabolite (-)-spirofungin A (1) is described. A key..

Total Synthesis of the Potent Anticancer Aglaia Metabolites (-)-Silvestrol and (-)-Episilvestrol and the Active Analogue (-)-4-Desmethoxyepisilvestrol

TE Adams, ME Sous, BC Hawkins, S Hirner, G Holloway, ML Khoo, DJ Owen, G Paul Savage, PJ Seammells, MA Rizzacasa

2009-02-04

Total synthesis of the anticancer 1,4-dioxane containing natural products silvestrol (1) and episilvestrol (2) is described by an ..

University of Melbourne Researchers

Mark Rizzacasa